Dear Colleagues,

The prevalence of type 1 diabetes is steadily increasing, especially in developed countries. Despite significant improvements in the diagnosis, prevention and treatment of diabetes complications based on interdisciplinary diabetes care, its chronic complications in the form of microangiopathies and macroangiopathies are a major cause of disability and reduced quality of life. In addition, mortality in type 1 diabetes remains two to eight times higher than in the general population. The main causes of mortality are cardiovascular complications, including cardiovascular and cerebrovascular events. The pathophysiological and morphological basis for the development of diabetic complications remains unclear. Endothelial damage during hyperglycemia and persistent inflammation in the microcirculation are responsible for microangiopathies such as retinopathy, neuropathy, nephropathy or cutaneous angiopathy. Another factor that increases inflammation in type 1 diabetes is the autoimmune nature of the disease. Many studies are devoted to investigating the impact of gene polymorphisms on the development of diabetic complications and searching for potential treatments. Personalization of preventive and therapeutic interventions is important. Undoubtedly, the future of type 1 diabetes treatment is linked to regenerative medicine.

This Special Issue of the International Journal of Molecular Sciences focuses on the latest research on the pathogenesis, early diagnosis or treatment of type 1 diabetes and its complications with both conventional and innovative technologies. This Special Issue welcomes in vitro and in vivo studies, as well as original research and reviews.

Dr. Jolanta Neubauer-Geryk

Guest Editor

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